| 早发性精神分裂症核心家系的亚甲基四氢叶酸还原酶基因传递不平衡研究 |
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| 引用本文： | 张晨,谢斌,方贻儒,程文红,杜亚松,汪栋祥,易正辉,禹顺英.早发性精神分裂症核心家系的亚甲基四氢叶酸还原酶基因传递不平衡研究[J].临床精神医学杂志,2010,20(2). |
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| 作者姓名： | 张晨 谢斌 方贻儒 程文红 杜亚松 汪栋祥 易正辉 禹顺英 |
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| 作者单位： | 上海交通大学医学院附属精神卫生中心,200030 |
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| 基金项目： | 国家自然科学基金(编号:30500181) |
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| 摘 要： | 目的:在中国汉族早发性精神分裂症家系中探讨亚甲基四氢叶酸还原酶(MTHFR)基因与精神分裂症的相关性。方法:采用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)技术,检验111个早发性精神分裂症核心家系MTHFR基因A1298C和C677T多态性,并进行连锁不平衡检验(LD)以及传递不平衡检验(TDT)。结果:A1298C及C677T等位基因在父母与先证者间传递差异均无统计学意义(χ2=0.216,P=0.642;χ2=0.143;P=0.706);连锁不平衡检验表明A1298C与C677T之间存在中度连锁不平衡(D'=0.529);单体型TDT显示早发性精神分裂症核心家系中各单体型传递差异均无统计学意义(P>0.05)。结论:MTHFR基因A1298C及C677T多态性与早发性精神分裂症无明显关联。
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| 关 键 词： | 早发性精神分裂症 亚甲基四氢叶酸还原酶基因 连锁不平衡 传递不平衡 |
A family based association study of methylenetetrahydrofolate reductase (MTHFR)gene with early onset schizophrenia |
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| ZHANG Chen,XIE Bin,FANG Yi-ru,CHENG Wen-hong,DU Ya-song,WANG Dong-xiang,YI Zheng-hui,YU Shun-ying.A family based association study of methylenetetrahydrofolate reductase (MTHFR)gene with early onset schizophrenia[J].Journal of Clinical Psychological Medicine,2010,20(2). |
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| Authors: | ZHANG Chen XIE Bin FANG Yi-ru CHENG Wen-hong DU Ya-song WANG Dong-xiang YI Zheng-hui YU Shun-ying |
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| Institution: | ZHANG Chen,XIE Bin,FANG Yi-ru,CHENG Wen-hong,DU Ya-song,WANG Dong-xiang,YI Zheng-hui,YU Shun-ying.Shanghai Mental Health Centre Affliated to Medical College of Jiaotong University,Shanghai 200030,China |
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| Abstract: | Objective:To investigate the association between methylenetetrahydrofolate reductase(MTHFR)gene and schizophrenia in Chinese early onset schizophrenia schizophrenic family trios. Method:The polymorphisms of MTHFR A1298C and C677T were detected with PCR-RFLP in 111 families trios.The linkage disequilibrium test(LD)and transmission disequilibrium test(TDT)were used to analyze the association between MTHFR and the disease. Results:There were no significant differences in alleles frequencies of the SNPs transmi... |
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| Keywords: | early onset schizophrenia methylenetetrahydrofolate reductase gene linkage disequilibrium transmit disequilibrium test |
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