麻仁软胶囊联合双歧杆菌乳杆菌三联活菌片治疗热积证功能性便秘的疗效观察

目的观察麻仁软胶囊联合双歧杆菌乳杆菌三联活菌片治疗热积证功能性便秘的临床疗效。方法选取2016年9月—2017年9月天津中医药大学第一附属医院、天津北辰区中医院收治的功能性便秘患者64例,随机分为对照组(30例)和治疗组(34例)。对照组患者口服双歧杆菌乳杆菌三联活菌片,4片/次,3次/d。治疗组患者在对照组的基础上口服麻仁软胶囊,2粒/次,1次/d。两组患者均连续治疗4周。观察两组患者临床疗效,比较治疗前后两组患者临床症状积分、中医症状评分和焦虑自评量表(SAS)评分。结果治疗后,对照组和治疗组的总有效率分别为80.00%和91.18%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者排便频率、排便速度、排便时间、排便费力、粪便性状积分,腹胀、腹痛、口臭、口干中医症状评分较治疗前均显著降低,同组比较差异具有统计学意义(P0.05);且治疗后治疗组上述评分均显著低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者SAS评分显著降低,同组治疗前后比较差异具有统计学意义(P0.05);且治疗后治疗组SAS评分显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论麻仁软胶囊联合双歧杆菌乳杆菌三联活菌片治疗热积证功能性便秘临床疗效较好,可显著改善临床症状和焦虑症状,具有一定的临床推广应用价值。

Clinical observation on Maren Soft Capsules combined with Live Combined Bifidobacterium and Lactobacillus Tablets in treatment of functional constipation with heat syndrome

Objective To observe the clinical effect of Maren Soft Capsules combined with Live Combined Bifidobacterium and Lactobacillus Tablets in treatment of functional constipation with heat syndrome. Methods Patients (64 cases) with functional constipation with heat syndrome in First Teaching Hospital of Tianjin University of TCM and Tianjin Beichen District Chinese Medicine Hospital from September 2016 to September 2017 were randomly divided into control (30 cases) and treatment (34 cases) groups.Patients in the control group were po administered with Live Combined Bifidobacterium and Lactobacillus Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Maren Soft Capsules on the basis of the control group, 2 grains/time, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, TCM symptom scores, and SAS score in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.00% and 91.18%, respectively, and there was difference between two groups (P < 0.05). After treatment, defecation frequency, defecation speed, defecation time, defecation laborious, stool character scores, and abdominal distension, abdominal pain, bad breath, dry mouth scores in two groups were decreased, and the difference was statistically significant in the same group (P < 0.05). And these scores in the treatment group were lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, SAS score in two groups was decreased, and the difference was statistically significant in the same group (P < 0.05). And SAS score in the treatment group was lower than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Maren Soft Capsules combined with Live Combined Bifidobacterium and Lactobacillus Tablets has clinical curative effect in treatment of functional constipation with heat syndrome, can improve clinical symptom and anxiety symptom, which has a certain clinical application value.