| 中药药效物质基础主要研究方法概述 |
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| 引用本文： | 汪小莉,刘晓,韩燕全,汪永忠,周珊珊,蔡宝昌,周导.中药药效物质基础主要研究方法概述[J].中草药,2018,49(4):941-947. |
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| 作者姓名： | 汪小莉 刘晓 韩燕全 汪永忠 周珊珊 蔡宝昌 周导 |
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| 作者单位： | 安徽中医药大学第一附属医院, 国家中医药管理局中药制剂三级实验室, 安徽 合肥 230031,南京中医药大学, 江苏 南京 210023,安徽中医药大学第一附属医院, 国家中医药管理局中药制剂三级实验室, 安徽 合肥 230031,安徽中医药大学第一附属医院, 国家中医药管理局中药制剂三级实验室, 安徽 合肥 230031,安徽省胸科医院, 安徽 合肥 230031,南京中医药大学, 江苏 南京 210023,安徽中医药大学第一附属医院, 国家中医药管理局中药制剂三级实验室, 安徽 合肥 230031 |
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| 基金项目： | 安徽中医药大学科研项目（2018zrzd14）；安徽省自然科学基金项目（1708085MH196）；安徽省卫生计生委中医药科研课题（2016zy03）；国家中医药管理局临床中药学重点学科建设项目（国中医药人教发[2012]32号）；2015年中医药部门公共卫生专项基金项目“中药炮制技术传承基地建设” |
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| 摘 要： | 研究中药药效物质基础对于阐明中药作用机制和提高中药质量标准具有关键的作用,中药药效物质基础研究方法主要包括:血清药物化学、谱效相关和药动学-药效学(PK-PD)模型研究等方面。通过查阅相关文献,对中药药效物质基础的主要研究方法进行综述,为阐明中药复方的药效物质基础提供参考。
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| 关 键 词： | 中药复方 药效物质基础 血清药物化学 谱效相关 PK-PD模型 |
| 收稿时间： | 2017/8/17 0:00:00 |
Overview on main research method of effective material basis of Chinese materia medica |
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| WANG Xiao-li,LIU Xiao,HAN Yan-quan,WANG Yong-zhong,ZHOU Shan-shan,CAI Bao-chang and ZHOU Dao.Overview on main research method of effective material basis of Chinese materia medica[J].Chinese Traditional and Herbal Drugs,2018,49(4):941-947. |
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| Authors: | WANG Xiao-li LIU Xiao HAN Yan-quan WANG Yong-zhong ZHOU Shan-shan CAI Bao-chang and ZHOU Dao |
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| Institution: | Grade 3 Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230031, China,Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China,Grade 3 Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230031, China,Grade 3 Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230031, China,Anhui Chest Hospital, Hefei 230031, China,Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China and Grade 3 Laboratory of TCM Preparation, State Administration of Traditional Chinese Medicine, The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei 230031, China |
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| Abstract: | Studies on the effective material basis of Chinese materia medica (CMM), which is critical for clarifying the mechanism of action and control quality. The main research methods on the effective material basis of CMM were reviewed through consulting relevant literature in this paper. It mainly includes the serum pharmaceutical chemistry, spectrum-effect and PK/PD model research. |
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| Keywords: | Chinese materia medica formula effective material basis serum pharmacochemistry spectrum-effect correlation PK-PD model |
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