接骨七厘片联合鹿瓜多肽治疗四肢骨折的疗效观察

目的探讨接骨七厘片联合鹿瓜多肽治疗四肢骨折的临床有效性与安全性。方法选取2012年6月—2015年6月天津市第五中心医院收治的四肢骨折患者82例,根据用药方案不同分成对照组和治疗组,每组各41例。对照组患者静脉滴注注射用鹿瓜多肽,24 mg加入生理盐水,1次/d;治疗组患者在对照组基础上口服接骨七厘片,5片/次,2次/d。两组患者均连续治疗8周。观察两组患者临床疗效,比较治疗前后两组患者四肢骨折愈合时间、视觉模拟评分(VAS)评分和SF-36评分。结果治疗后,对照组临床总有效率为78.05%,显著低于治疗组的95.12%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患者胫骨干、尺桡骨、股骨干、肱骨干骨折愈合时间均明显短于对照组患者,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者VAS评分显著降低,SF-36评分显著升高,同组比较差异具有统计学意义(P0.05);且治疗组患者VAS评分和SF-36评分改善情况明显优于对照组(P0.05)。结论接骨七厘片联合鹿瓜多肽治疗四肢骨折可显著提升患者的临床有效率,改善患者的疼痛症状与生活质量。

Clinical observation of Jiegu Qili Tables combined with cervus and cucumis polypeptide in treatment of limbs fracture

objective To explore the clinical efficacy and safety of Jiegu Qili Tables combined with cervus and cucumis polypeptide in treatment of limbs fracture. Methods Patients (82 cases) with limbs fracture in Tianjin Fifth Central Hospital from June 2012 to June 2015 were divided into control and treatment groups according to different treatments, and each had 41 cases. Patients in the control group were iv administered with Cervus and Cucumis Polypeptide for injection, 24 mg added into normal saline, once daily. Patients in the treatment group were po administered with Jiegu Qili Tables on the basis of the control group, 5 tables/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the healing time of fracture of limbs, VAS scores, and SF-36 scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 78.05%, which was significantly lower than 95.12% in the treatment group, and there were differences between two groups (P < 0.05). After treatment, the healing time of fracture of tibial diaphysis, ulnar and radial bone, femoral shaft, and humeral diaphysis in the treatment group were obviously shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the VAS scores in two groups were significantly decreased, but the SF-36 scores were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the improvement of VAS and SF-36 scores in the treatment group were significantly better than that in the control group (P < 0.05). Conclusion Jiegu Qili Tables combined with cervus and cucumis polypeptide can improve the clinical efficiency in treatment of limbs fracture, and improve the pain symptoms and quality of life.