小儿消积止咳口服液联合注射用炎琥宁治疗儿童支原体肺炎的临床研究

目的探讨小儿消积止咳口服液联合注射用炎琥宁治疗儿童支原体肺炎的临床疗效。方法选取2016年6月—2017年6月在上海市第十人民医院治疗的支原体肺炎患儿98例,随机分为对照组和治疗组,每组各49例。对照组患儿静脉滴注注射用炎琥宁,每次5~10 mg/kg加入10%葡萄糖溶液55~250 m L,1次/d;治疗组在对照组的基础上口服小儿消积止咳口服液,5岁以下患儿0.2 g/次,大于5岁0.3 g/次,3次/d。两组患儿均治疗7 d。观察两组患儿临床疗效,比较治疗前后两组患儿临床症状消失时间和住院时间以及血清细胞因子水平和C反应蛋白(CRP)水平。结果治疗后,对照组和治疗组临床总有效率分别为77.55%、87.76%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患儿的退热时间、啰音消失时间、咳嗽好转时间和平均住院时间明显短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患儿血清细胞因子水平和CRP水平均明显降低(P0.05);同时治疗组患儿血清细胞因子水平和CRP水平均明显低于对照组(P0.05)。结论小儿消积止咳口服液联合注射用炎琥宁可明显改善支原体肺炎患儿的临床症状,缩短住院时间,具有一定的临床推广应用价值。

Clinical study on Xiaoer Xiaoji Zhike Oral Liquid combined with Potassium Sodium Pehydroandrographolide Succinate for injection in treatment of children with mycoplasma pneumonia

objective To investigate the clinical efficacy of Xiaoer Xiaoji Zhike Oral Liquid combined with Potassium Sodium Pehydroandrographolide Succinate for injection in treatment of children with mycoplasma pneumonia. Methods Children (98 cases) with mycoplasma pneumonia in Shanghai Tenth People''s Hospital from June 2016 to June 2017 were randomly divided into control (49 cases) and treatment (49 cases) groups. Children in the control group were iv administered with Potassium Sodium Pehydroandrographolide Succinate for injection, 5-10 mg/kg added into 10% glucose solution 55-250 mL, once daily. Children in the treatment group were po administered with Xiaoer Xiaoji Zhike Oral Liquid on the basis of the control group, 0.2 g/time for children under 5 years, and 0.3 g/time for older than 5 years, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the clinical symptom disappearance time, average hospitalization time, serum cytokine and CRP levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 77.55% and 87.76%, respectively, and there were differences between two groups (P < 0.05). After treatment, the antipyretic time, rale disappearance time, cough improvement time, and average hospitalization time in the treatment group was significantly shorter than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the serum cytokine and CRP levels in two groups were obviously decreased (P < 0.05). And these indexes levels in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Xiaoer Xiaoji Zhike Oral Liquid combined with Potassium Sodium Pehydroandrographolide Succinate for injection in treatment of children with mycoplasma pneumonia can significantly improve clinical symptoms and shorten the hospitalization time, which has a certain clinical application value.