肿瘤抑制因子P33ING1b的研究进展

生长抑制因子（inhibitor of growth．ING）家族是学者在筛选生长抑制基因的过程中检测到其成员之一的INGl而偶然发现的一个新家族，已被归入肿瘤抑制基因家族这个正在不断发展的群体。该群体的成员含有一系列与转录调控相关的结构序列。能编码相应的蛋白因子。其中，P33INGIb是ING1的蛋白产物之一，具有多种生物学功能。本文收集近年相关资料，就P33ING1b的基因定位、基因结构、功能、故障原因及其与某些皮肤病的关系综述如下．为相关研究及临床应用开拓新思路。第一段]

Research advancement of tumor suppressor gene family ING and its product P33ING1b

P33ING1b is a new tumor suppressor protein that found recently. It is the most widely expressed product of gene ING1, which is one member of new gene family inhibitor of growth(ING). P33ING1b has many biological functions, such as modulation of cell cycle check points, promoting apoptosis, inhibiting tumour anchorage independent growth, etc. P33ING1b expresses less or none in nucleus as well as more in endochylema in some innocent tumors and almost every kind of malignant tumor, which is maybe the major agent that leads to its loss of tumor suppression. Such achievements expand new pathway for science research and clinic application.