三七抗肝纤维化的实验研究

目的 探讨三七对四氯化碳（ＣＣＬ）中毒性肝纤维化的防治作用。方法 复制大鼠ＣＣＩ４中毒性肝纤维化模型，并以秋水仙碱作为阳性治疗对照。采用光镜、电镜观察组织学改变，测定血清丙氨酸氨基转移酶（ＡＬＴ）、白蛋白、球蛋白、透明质酸（ＨＡ）、层粘连蛋白（ＬＮ）、肝组织羧脯氨酸（Ｈｙｐ）含量，以反映肝细胞损伤及肝纤维化程度。将形态改变与功能变化相结合对比分析三七对ＣＣＩ４中毒性肝纤维化的防治作用。结果 三七治

Effects of Panax Notogenseng on CCl4-induced liver fibrosis in rats

Objective To investigate the effects of Panax Notoginseng (PN) on liver fibrosis (LF) induced with CCl4. Methods The model of CCl4-induced LF was established in rats and they were treated with PN or colchicine (Col). The histological changes were obseved with light and electron microscopy. Serum level of alanine aminotransferase (ALT), albumin, globulin, hyaluronic acid (HA) and laminin (LN) and hydroxyproline (Hyp) in liver tissues were determined to reveal the extent of liver damages. The Col-treated group served as the positive control. Results The extent of liver damages, fatty degeration and infiltration of inflammatory cells were less severe in the PN treated group than in the Col-treated group. The formation of fibroblasts and collagenous fibers was less in amount in the PN-treated group than in the Col-treated group.Conclusion PN exerts a protective effect on CCl4-induced LF in rats and inhibits the formation of fibroblasts and collagenous fibers in liver tissues.