| 参三七皂甙Rg1对实验性血栓形成的影响及其机制探讨 |
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| 引用本文： | 徐皓亮 刘宛斌. 参三七皂甙Rg1对实验性血栓形成的影响及其机制探讨[J]. 药学学报, 1997, 32(7): 502-506 |
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| 作者姓名： | 徐皓亮 刘宛斌 |
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| 作者单位： | 南京医科大学心血管药理研究室 |
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| 摘 要： | 用大鼠动静脉血栓形成模型，研究参三七皂甙Ｒｇ１抗血栓作用。结果表明，参三七皂甙Ｒｇ１可明显降低实验性血栓形成，对大鼠血浆纤溶系统亦有明显作用，可升高血浆中组织纤溶酶原激活物（ｔＰＡ）活性和活性型ｔＰＡ百分比，降低组织纤溶酶原激活物抑制剂（ＰＡＩ）活性。同时利用培养大鼠血管内皮细胞实验，发现Ｒｇ１可以剂量依赖性提高血管内皮细胞一氧化氮（ＮＯ）释放。提示Ｒｇ１抗血栓作用与增强纤溶系统活性，促进血管内皮ＮＯ释放有关
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| 关 键 词： | 参三七皂甙Rg1；血栓形成；组织纤溶酶原激活物；纤溶酶原激活物抑制剂；一氧化氮 |
EFFECT OF SANCHINOSIDE Rg 1 ON EXPERIMENTAL THROMBOSIS AND ITS MECHANISMS |
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| HL Xu,WB Liu and MR Rao. EFFECT OF SANCHINOSIDE Rg 1 ON EXPERIMENTAL THROMBOSIS AND ITS MECHANISMS[J]. Acta pharmaceutica Sinica, 1997, 32(7): 502-506 |
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| Authors: | HL Xu WB Liu MR Rao |
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| Affiliation: | Department of Cardiovascular Pharmacology, Nanjing Medical University, 210029. |
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| Abstract: | The effect of sanchinoside Rg 1 on generation of thrombosis and its mechanism was studied. Rg 1 was shown to markedly inhibit experimental thrombosis formation induced by extra corporeal shunt between the carotid artery and jugular vein. After Rg 1 infusion, the activity of t PA was found to be increased, so did the percentage of active type t PA, but the activity of PA I decreased. Further data in our study indicate that incubation of endothelial cells with Rg 1 for 24 h caused significant increase of NO production. This effect was found to be dose dependent. These observations suggest that Rg 1 is a potent anti thrombosis substance and can enhance the function of fibrinolysis system and stimulate vascular endothelial cells to release NO. |
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| Keywords: | Sanchinoside Rg 1 Thombosis Tissue plasminogen activator Plasminogen activator inhibitor Nitric oxide |
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