MMP2和MMP9在非小细胞肺癌组织中的表达

目的研究肺癌和正常肺组织中基质金属蛋白酶MMP2和MMP9的表达.方法采用免疫组织化学方法检测31例非小细胞肺癌(NSCLC)组织标本和10例正常肺组织MMP2和MMP9的表达.结果 NSCLC者MMP2表达阳性19例(61.3%),MMP9表达阳性26例(83.9%).正常肺标本MMP2和MMP9表达均为阴性.NSCLC与正常肺标本比较差异均有显著意义(P《0.05).结论在NSCLC中,高表达的MMP2和MMP9均是良好的肿瘤标记物,MMP9阳性率比MMP2更高,因此MMP9的检测具有更大的临床意义.

The expression of MMP2 and MMP9 in non small cell lung cancer

Objective To study the expression of matrix metalloproteinase 2(MMP 2) and matrix metalloproteinase 9(MMP 9) in non small cell lung cancer(NSCLC).Methods Immunohistochemical technique was used to detect the expression of MMP 2 and MMP 9 in 31 cases of NSCLC and 10 cases of normal lung tissue.Results The positive expression of MMP 2 and MMP 9 was demonstrated 61.3%(19/31) and 83.9%(26/31)respectively.The positive immunoreactivities of MMP 2 and MMP 9 were all negative among 10 normal lung specimens.The expressionS of MMP 2 and MMP 9 in NSCLC were significantly different with the normal lung specimens.Conclusion MMP 2 and MMP 9 have high expressions in NSCLC and they were good tumor markers.The positive rate of MMP 9 is higher than MMP 2,detection of MMP 9 has more clinical significance.