阿立哌唑与利培酮治疗精神分裂症的对照研究

目的：观察阿立哌唑的疗效及安全性。方法：采用随机、单盲、对照的设计原则将64例精神分裂症患者分为阿立哌唑组与利培酮组，疗程为4周。在治疗前、治疗1、2、4周采用PANSS量表评定疗效，TESS量表、实验室检查及体检评定安全性。结果：两组总体疗效相当，阿立哌唑对以阴性症状为主要表现的患者疗效优于利培酮组。不良反应：锥体外系反应利培酮组明显高于阿立哌唑组（P〈0．01）。结论：阿立哌唑治疗以阴性症状为主的精神分裂症的疗效、耐受性及依从性均较好。

Comparative study of Aripiprazole and Risperridone for schizophrenia

Objective: To verify the efficacy and side effects of Aripiprazole on schizophrenia. Method: Patients who met CCMD-3 criteria for schizophrenia were randomized into two groups:Aripiprazole group and Risperidone group in a case -control study.The treatment duration was 4 weeks. The PANSS,TESS,related lab tests and physical examination were employed for assessing the treatment effectiveness and side effects.Result: At the end of treatments,the scores of the PANSS at the end of 4 weeks had no significant difference between the two groups.The patients with positive symptoms had a poor efficacy in Aripiprazole group than that in Risperidone group,while patients with negative symptoms had a better efficacy in Aripiprazole group than in Risperidone group.And patients used Aripiprazole had fewer side effects than those in Risperidone group,especially in the items of reduced external pyramidal syndrome (EPS).Conclusion: Aripiprazole has a better efficacy to schizophrenia patients with more negative symptoms and has a good tolerance and compliant.