Voltage-gated calcium channels in chronic pain: emerging role of alternative splicing |
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Authors: | Leigh Anne Swayne Emmanuel Bourinet |
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Institution: | (1) Département de Physiologie, Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094 Montpellier, France;(2) CNRS UMR5203, INSERM U661, IFR3, Universités Montpellier I and II, Montpellier, France |
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Abstract: | N- and T-type voltage-gated calcium channels are key established players in chronic pain. Current work suggests that alternative
splicing of these channels constitutes an important aspect in the investigation of their roles in the pathogenesis of chronic
pain. Recent N-type channel studies describe a nociceptor-enriched alternatively spliced module responsible for voltage-independent
G protein modulation and internalization, which is implicated in the control of distinct nociceptive pathways. On the contrary,
although a large body of work has demonstrated that peripheral Cav3.2-encoded T-type currents are involved in several types of chronic pain, little is known with respect to the expression
of numerous newly discovered splice variants in specific pain pathways. The elucidation of the new layers of molecular complexity
uncovered in N- and T-type channel splice variants and their respective locations and roles in different pain pathways will
allow for the development of better therapeutic strategies for the treatment of chronic pain. |
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Keywords: | Pain Calcium channel Dorsal root ganglion Dorsal horn Neurotransmission |
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