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| Bcl-2、P53和Bax在尖锐湿疣组织中的表达及意义研究 | |
| 引用本文： | 尹光文,赵卫华,张云汉,傅世珍. Bcl-2、P53和Bax在尖锐湿疣组织中的表达及意义研究[J]. 中国现代医学杂志, 2006, 16(2): 216-218 |
| 作者姓名： | 尹光文 赵卫华 张云汉 傅世珍 |
| 作者单位： | 1. 郑州大学第一附属医院,皮肤性病科,河南,郑州,450052 2. 广东省惠州市皮防所 3. 郑州大学第一附属医院,病理科,河南省肿瘤病理重点实验室,河南,郑州,450052 |
| 摘 要： | 目的探讨尖锐湿疣（CA）组织中Bcl-2、Bax和P53蛋白的表达及其与CA发病的关系。方法采用免疫组织化学SP法分别检测28例CA组织和14倒正常上皮组织中Bcl-2、Bax和P53蛋白的表达情况。结果28倒CA组织中Bcl-2、Bax和P53蛋白表达率分别为46．43％、75.00％和71．43％，而在正常上皮组织中的表达平分别为14.29％、57．14％和28.57％，Bcl-2、P53的表达在正常组织和CA组差异有显著性（P〈0.05）：Bcl-2和Bax的表达呈负相关（rs=-0.611，P〈0.05）。结论CA组织中Bcl-2、Bax和P53蛋白表达异常及其Bcl-2和Bax二者的相关性可能与CA的者病有关。 |
| 关 键 词： | 细胞凋亡 尖锐湿疣 |
| 文章编号： | 1005-8982（2006）02-0216-03 |
| 收稿时间： | 2005-03-04 |
| 修稿时间： | 2005-03-04 |
Expression and significance of Bcl-2, P53 and Bax protein in condyloma acuminata |
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| YIN Guang-wen,ZHAO Wei-hua,ZHANG Yun-han,FU Shi-zhen. Expression and significance of Bcl-2, P53 and Bax protein in condyloma acuminata[J]. China Journal of Modern Medicine, 2006, 16(2): 216-218 | |
| Authors: | YIN Guang-wen ZHAO Wei-hua ZHANG Yun-han FU Shi-zhen |
| Affiliation: | 1. Department of Dermatology and Venerology, Zhengzhou, Henan 450052, P.R.Chian; 2. Department of Pathology, Key Lab of Oncological Pathology in Henan, the First Affiliated Hospital of Zhengzhou, University, Zhengzhou, Henan 450052, P.R.China |
| Abstract: | [Objective] To detect the expression and significance of Bcl-2, Bax and P53 in keratinocytes of condyloma acuminatum (CA), and explore their roles in pathogenesis. [Methods] The expression of Bcl-2, Bax and P53 protein in 28 cases of CA and 14 normal controls were detected respectively by immunohistochemistry staining (SP). [Results] The positive expression rates of Bcl-2 and P53 in CA were significantly higher than those in normal samples (P <0.05), and there was a negatitive correlation between Bcl-2 and Bax expression (r =-0.611, P <0.05). [Conclusion] Bcl-2, Bax and P53 may play great role in CA pathogenesis. |
| Keywords: | Bcl-2 P53 Bax |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |