超常胎盘部位临床病理及免疫组化研究

目的：研究超常胎盘部位９ＥＰＳ）的病理特点与临床表现的关系。方法：应用免疫组化ＡＢＣ法对１８例ＥＰＳ病变进行研究，并结合临床表现进行病理分析。结果：ＥＰＳ是中间型滋养细胞在胎盘部位非破坏性的浸润肌层和血管壁，而不形成肿块，胎盘泌乳素（ＨＰＬＣ）和ＣＫ强阳性或阳性，两者细胞定位相同。ＨＣＧ阳性或弱阳性或弱阳性，与ＨＰＬ定位一致或不一致。部分病例ＣＥＡ少量细胞阳性。患者可表现ＨＣＧ下降缓慢或产后出血。

Study on clinical pathology and immunohistochemistry of exaggerated placental sitc

Purpose To study the pathological features and relationship with clinical aspects of exaggeratedplacental site (EPS). Methods Eighteen cases with EPS were investigated at the light microscope level and byimmunohistochemical staining and analyzed in combination with clinical symptoms. Results EPS was that intermediate trophoblast (IT) Infiltrated undestructively into the myometrium layers and the wall of the vessel inthe placental site but formed no tumour. human placental lactogen (HPL) and cytokeratin (CK) were stronglypositive or positive expression and both were alike on the cellular location. HCG was positive or weakly positive.The expressed positions of HCG were identical or not with HPL. In a few cells in the partial cases, CEA waspositive. The patient may show slower drop of the serum HCG and postpartum hemorrhage. Conclusion EPSwas correlated with pregnancy. Hypoplasia or absence of decidua was one of easily-happening factors. Some cases may expand into transitional form of placental site trophoblastic tumour. Varying sub-groups of IT exist anddevelop along syncytiotrophoblast with immunohistochemical characteristics.