Bestatin administration and the change in cellular immunity |
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| Authors: | H Yamagishi K Naito Y Ueda S Itoi H Kohnosu M Kobayashi H Kubo A Matsuda T Oka |
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| Affiliation: | 2nd Dept of Surgery, Kyoto Prefectural University of Medicine, Japan. |
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| Abstract: | The change in cellular immunity by Bestatin (ubenimex) treatment--30 mg/day orally--was investigated in 23 gastrointestinal cancer patients for: 1), functional T cell subsets; 2), IL-2 receptor; 3), PHA-induced blastogenesis; and 4), PPD skin reaction. The absolute number of helper T cells (Th) and cytotoxic T cells (Tc) increased in 74 and 79% of cases, respectively, compared with pretreatment values. On the other hand, the absolute number of suppressor T cells (Ts) decreased in 79% of cases. IL-2 receptor increased in 56% of patients, PHA blastogenesis increased in 67% of patients and PPD skin reaction was elevated in 75% of cases comparing to pretreatment values. These results suggest that Bestatin could increase cellular immunity in cancer patients. |
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