Detection of human papillomavirus (HPV) type 16 DNA relative sequence in the tissue of laryngeal carcinoma]

By using alpha 32-P-dCTP labeled Chinese Human papillomavirus type 16 DNA (CHPV 16 DNA) probe, we have adopted Southern blot method and detected HPV subtype 16 DNA (1/6) and HPV 16 DNA relative sequence (3/6) in 6 biopsy specimens of laryngeal carcinoma. The result showed a severe infection of HPV in laryngeal carcinoma. This indicates that HPV infection may play a pathogenetic role in the cancer.