Antitumor activity of orally administered streptococcal preparation, OK-432 on murine solid tumors and its absorption from the gut |
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| Authors: | Y Nio T Shiraishi T Tsuchitani T Tobe Y Sugawara M Saito H Kamiyama |
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| Institution: | Division of Surgical Oncology, Kyoto University Faculty of Medicine, Japan. |
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| Abstract: | OK-432 is an immunopotentiator which is normally administered by injection. In the present study, the antitumor activity of orally administered OK-432 on various solid tumors and the absorption of OK-432 from the gut were studied. Orally administered OK-432 inhibited the growth of Meth-A and BAMC-1 fibrosarcomas which had been subcutaneously transplanted in BALB/c mice. Autoradiograms of mice which had been administered 14C-labelled OK-432 orally demonstrated the absorption of OK-432 from the gut, and about 6% of orally administered OK-432 was absorbed 24 hrs after its administration. Moreover, an immunofluorescent study using an anti-OK-432 antibody revealed specific fluorescence in the mesenteric lymph node of mice which had been orally administered with OK-432. These results suggest that oral administration of OK-432 may be a beneficial immunotherapy. |
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