Risk reduction of severe outcomes in vaccinated COVID-19 cases: an analysis of surveillance data from Estonia,Ireland, Luxembourg and Slovakia,January to November 2021 |
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| Authors: | Gaetano Marrone,Nathalie Nicolay,Nick Bundle,Tommi Karki,Gianfranco Spiteri,Heleene Suija,Kerstin-Gertrud Kä rblane,Joë l Mossong,Anne Vergison,Maria Avdicova,Adriana Mecochova,Gillian Cullen,Piaras O’ Lorcain,Lucia Pastore Celentano,Tarik Derrough,Julien Beauté |
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| Affiliation: | 1.European Centre for Disease Prevention and Control (ECDC), Solna, Sweden; 2.Republic of Estonia Health Board, Tallinn, Estonia; 3.Health Directorate, Luxembourg City, Luxembourg; 4.Regional Public Health Authority, Banska Bystrica, Slovakia; 5.Public Health Authority of the Slovak Republic, Bratslava, Slovakia; 6.Health Protection Surveillance Centre, Dublin, Ireland |
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| Abstract: | Despite high COVID-19 vaccine coverage in the EU/EEA, there are increasing reports of SARS-CoV-2 infections and hospitalisations in vaccinated individuals. Using surveillance data from Estonia, Ireland, Luxembourg and Slovakia (January–November 2021), we estimated risk reduction of severe outcomes in vaccinated cases. Increasing age remains the most important driver of severity, and vaccination significantly reduces risk in all ages for hospitalisation (adjusted relative risk (aRR): 0.32; 95% confidence interval (CI): 0.26–0.39) and death (aRR: 0.20; 95% CI: 0.13–0.29). |
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| Keywords: | COVID-19 surveillance vaccination vaccine effectiveness Europe Union hospitalization death |
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