| 单纯疱疹病毒感染兔脑膜和脑神经细胞的实验研究 |
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| 引用本文： | 姚苹,许洪芝,王桂亭,王志玉,丁守銮. 单纯疱疹病毒感染兔脑膜和脑神经细胞的实验研究[J]. 山东大学学报(医学版), 1998, 0(2) |
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| 作者姓名： | 姚苹 许洪芝 王桂亭 王志玉 丁守銮 |
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| 作者单位： | 山东医科大学公共卫生学院 |
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| 摘 要： | 为了观察单纯疱疹病毒（ＨＳＶ）对脑膜和脑实质的侵袭性，用不同剂量的ＨＳＶ体外感染兔脑膜及脑神经细胞，对病毒的感染强度作趋势检验，同时观察该病毒的致细胞病变作用及抗原分布。ＨＳＶ对体外兔脑膜和脑神经细胞均造成明显的病理损害，趋势分析Ｐ＞０．０５，两种细胞的胞浆与胞核中均有病毒抗原分布。体外实验提示ＨＳＶ对兔脑膜和脑神经细胞具有相同的侵袭性
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| 关 键 词： | 人疱疹病毒；脑膜；脑实质；体外；兔 |
HSV 1 INVASIVENESS IN MENINGES AND CEREBRAL NERVE CELLS OF RABBITS |
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| Yao Ping,Xu Hongzhi,Wang Guiting,et al. HSV 1 INVASIVENESS IN MENINGES AND CEREBRAL NERVE CELLS OF RABBITS[J]. Journal of Shandong University:Health Sciences, 1998, 0(2) |
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| Authors: | Yao Ping Xu Hongzhi Wang Guiting et al |
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| Abstract: | This experiment is to compare HSV 1 invasiveness in two different tissues,meningocyte and cerebral nerve cells in vitro.The cells were from New Zealand rabbits and taken primary cell culture.The two kinds of cells were infected with HSV 1 in various dosages when cells were cultured 5 to 7 days.Cell pathologic effect(CPE) was observed every 12h after infection and scored on the 7th day for trend analysis.The results showed HSV 1 can cause visible pathologic changes in both kinds of cells.The cytopathic effect was characterized by swelling,aggregation and fusion with cell lysis and death.Trend analysis showed P >0.05,which suggests HSV 1 invasiveness was of no significant difference in the two kinds of cell in vitro.Indirect immunofluorescence staining with human antiserum to HSV 1 was positive in the pathologic cells. |
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| Keywords: | Herpesvirus hominis Invasiveness Meninges Neurons In vitro Rabbits |
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