文拉法辛缓释剂与速释剂临床对照分析

目的：探讨文拉法辛缓释剂的疗效与不良反应。方法：将72例服用文拉法辛缓释剂患者（缓释剂组）与68例服用文拉法辛速释剂患者（速释剂组），从疗效和不良反应等方面进行对照研究。结果：缓释剂组起效时间较快，不良反应较少。速释剂组转躁者较多，排尿困难、癫痫、呕吐仅出现在速释剂组，但撤药反应仅发生于缓释剂组。两组治疗6周后无效的患者进行交叉用药，50．0％及53．3％的患者取得疗效。结论：文拉法辛缓释剂起效较快，不良反应较小，更适合用于临床。

Clinical comparative analysls on extended release and immediate release venlafaxine

Objective:To detect the efficacy and side effect of release venlafaxine. Method:The efficiency and side effect of extended released (72 cases,XR) and immediate release venlafaxine (68 cases,IR)were compared. Results:Extended release venlafaxine had faster in onset of effciency.Changed manic was more in group IR than that in group XR.Dysuria,epilepsy and vomit happened only in group IR,while drug-removing reaction occurred only in group XR.For patients without improvement after 6 weeks original treatment in XR group and IR group,they were shifted to the other group.Afterwards,50.0% and 53.3% of them experienced favorable results. Conclusion:Extended release venlafaxine has faster efficiency,milder side effects.It is more available in clinical use.