Xenograft rejection--all that glitters is not Gal. |
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Authors: | Ben Sprangers Mark Waer An D Billiau |
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Affiliation: | Laboratory of Experimental Transplantation, University of Leuven, Campus Gasthuisberg, O&N 811, Herestraat 49, B-3000 Leuven, Belgium. |
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Abstract: | Xenotransplantation is being developed in the hope of resolvingthe critical shortage of donor organs for transplantation. TheEurotransplant waiting lists [1] for donor organs of variouskinds number almost 16 000 patients and the US lists [2] morethan 90 000 patients. Renal transplantation, for instance, cost-effectivelyconfers a significant survival advantage [3] and improvementof quality of life [4]. But whereas currently, in Europe, nearly12 000 end-stage renal disease patients await a suitable donor,only 3383 kidney transplants were performed in 2005, with anaverage waiting time of 1174 days [1]. Substantial researchefforts are being made in the field of xenotransplantation,and the immunological barriers are gradually being elucidated.Pig-to-human xenogeneic |
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Keywords: | xenotransplantation kidney GAL |
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