慢性阻塞性肺疾病肺通气与血浆TXB_2、6-K-PGF_(1a)及免疫状态的关系

对85例慢性阻塞性肺疾病（COPD）患者进行了1s率（FEV1％），最大呼气中期流速（MMEF），血栓素B2（TXB2），6－酮－前列腺素F1a（6K－K－PGF1a），T淋巴细胞总数（T3）及亚群（T4，T8），IgA、G、M测定。结果：FEV1％降低，血浆中TXB2浓度升高，TXB2／6－K－PGF1a比值增大，外周血中T4减少，T8增多，T4／T8比值下降。MMEF重度降低时，TXB2和TXB2／6K－K－PGF1a升高，IgG改变显著，T4减少，T4／T8比值降低。T4／T8比值降低患者，血浆中TXB2浓度升高，TXB2／6－K－PGF1a比值增大，差异显著。结果提示：COPD患者可能有TXB2／6－K－PGF1a平衡紊乱，免疫功能改变，T4／T8比值改变可能影响TXB2／6－K－PGF1a平衡。大气道和小气道发生和发展机制不完全相同。

Correlation between plasmatic TXB_2 and 6-K-PGF_(1a)and the immune status in chronic obstruction pulmonary disease

FEV1 % MMEF, plasmatic TXB2and 6-K-PGF1a, total number of T lymphocyte(T3) and T-lymphocyte subsets (T4, T8 ), and plasmatic IgA. G. M were determined in eight-five chronic obstruction pulmonary disease patients. The results revealed that when FEV1 % Lowered, the plasmatic concentration of TXB2 and the ratio of TXB2/6-K-PGF1a increased, the number of T4 decreased and the number of T8 increased with the low ratio of T4/T8, that the TXB2 elevated with the high ratio of TXB2/6-K-PGF1a, IgG increased, and the number of T4 and the ratio of T4/T8 decreased in seriously lowered MMEF group and that TXB2 and the ratio of TXB2/6-K-PGF1a increased in lowered T4/T8. The findings suggested that there might be TXB2 and 6-K-PGF1a imbalance and immunological changes in COPD patients, and that the ratio of T4/T8 might affect the balance of TXB2/6-K-PGF1a and there were different roles between large airways and small airways in pathogenesis of COPD.