Selection of Routine Method for Determination of Glomerular Filtration Rate in Adult Patients |
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Authors: | J. Bröchner-Mortensen P. Rödbro |
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Affiliation: | Dept. of Clinical Physiology and Medicine C (Nephrology), Aalborg Sygehus, Aalborg, Denmark |
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Abstract: | The precision and reproducibility of three different clearance methods as used in clinical routine assessment of glomerular filtration rate (GFR) were investigated in 51 patients: total [51Cr]EDTA plasma clearance (E); 24-hr endogenous creatinine clearance (C); and creatinine clearance estimated from the plasma creatinine concentration, weight, and sex-and age-dependent mean creatinine excretion rate (c). The precision and reproducibility (coefficient of variation) for single determinations were, in patients with E ≥ 30 ml/min, 5.5 and 4.1% (E); 26.9% (C); and 23.2 and 11.0% (c). The corresponding figures for E < 30 ml/min were 11.6 and 11.5% (E); 21.9% (C); and 21.4 and 6.5% (c). The precision of C could not be ameliorated by excluding single deviating determinations, but only by excluding patients for whom the precision of 15.5% for mean of three determinations of C (total material) could be reduced to 10% by excluding 25% of the patients. The present data indicate that E in most cases is the method of choice for assessment of GFR in clinical routine work. For changes in renal function, especially at low functional levels, c may be of value. |
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Keywords: | [51Cr]EDTA plasma clearance endogenous creatinine clearance glomerular filtration rate plasma creatinine concentration precision reproducibility |
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