Intragastric Nitric Oxide/Nitrite in Helicobacter pylori-Infected Subjects |
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| Authors: | L Fändriks C von Bothmer A Åneman L Olbe A Pettersson |
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| Institution: | Depts. of Surgery, Physiology, Anaesthesiology and Intensive Care and Dept. of Clinical Pharmacology, G?teborg University, Sweden |
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| Abstract: | Background: Nitrite (NO2-) in swallowed saliva is reduced to nitric oxide (NO) and other nitrogen oxides by the intragastric acidity. This mechanism is probably important for the intragastric clearance of ingested micro-organisms and nitrosating compounds. The study examines the balance between intragastric NO and NO2- in relation to endogenous acid production and infection with Helicobacter pylori. Methods: Six healthy H. pylori-negative and six H. pylori-positive volunteers with no known gastroduodenal pathology were examined after an overnight fast. Gastric NO was measured using a chemiluminescence technique and pH as well as NO2- were analysed in gastric aspirates. Results: Gastric NO was slightly lower in H. pylori |
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| Keywords: | Helicobacter Pylori Nitric Oxide Ph Stomach |
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