Gene expression of natriuretic peptides and their receptors type-A and-C after myocardial infarction in rats |
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| Authors: | M E Hystad E Øie H K GrØgaard K Kuusnemi O Vuolteenaho H Attramadal C Hall |
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| Institution: | 1. Institute of Surgical Research, Merck Sharp &2. Dohme Cardiovascular Research Center;3. Department of Physiology, University of Oulu, Oulu, Finland;4. Institute of Internal Medicine, The National Hospital, University of Oslo, Oslo, Norway |
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| Abstract: | The purpose of this study was to investigate myocardial mRNA expression of brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) in different regions of the heart at three different time points after induction of myocardial infarction (MI) in rats. Furthermore, we examined putative changes in mRNA expression of natriuretic peptide receptors (NPRs), NPR-A and NPR-C, in myocardium and peripheral organs. Substantial increase in the mRNA levels of both BNP and ANP in the infarcted as well as non-infarcted regions were observed after induction of MI. These findings were paralleled by elevated circulating concentrations of ANP, BNP and N-terminal proANP (Nt-proANP). In addition, the mRNA levels of the clearance receptor, NPR-C, were augmented in the infarcted and non-infarcted regions of the left ventricular wall (LV), while it was decreased in the kidneys and lungs 28 days post-MI. Based on these data, we propose that, in addition to increased myocardial secretion of BNP and ANP, reduced peripheral clearance by NPR-C may contribute to the observed increase in circulating plasma concentrations of the natriuretic peptides after induction of MI in rats. |
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| Keywords: | Atrial Natriuretic Peptide Brain Natriuretic Peptide Clearance Receptor Experimental Heart Failure Rats Mrna Expression |
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