Thrombomodulin expression in endothelial cells after contact with bone cement |
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| Authors: | Cenni Elisabetta Ciapetti Gabriela Granchi Donatella Savarino Lucia Corradini Alessandra Vancini Melania Di Leo Alessandro |
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| Affiliation: | Dipartimento Putti, Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy. elisabetta.cenni@ior.it |
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| Abstract: | The expression of thrombomodulin after contact with CMW 1 bone cement extracts was studied in human umbilical vein endothelial cells. Cement extracts after 1 h and 7-day curing induced no significant variations in thrombomodulin antigen levels and in mRNA expression. Significant increase of thrombomodulin was observed when endothelial cells were treated with all-trans retinoic acid (ATRA). ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW 1 bone cement does not impair the expression of thrombomodulin in endothelial cells. |
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