L-OHP联合5-Fu和CF治疗晚期大肠癌的疗效观察

目的观察奥沙利铂联合5-氟脲嘧啶、甲酰四氢叶酸钙治疗晚期大肠癌的近期疗效。方法对43例晚期大肠癌采用奥沙利铂130mg／m^2静脉点滴2h，第1天；甲酰四氢叶酸钙200mg／m^2静脉点滴2h，第1～5天；5-氟脲嘧啶400mg／m^2静脉点滴8h以上，第1～5天。结果全组CR 1例，PR 20例，总有效率为48．8％(21／43)，中位无进展生存期为10．1个月，中位生存期为20．7个月；主要不良反应为骨髓抑制、神经毒性反应，Ⅲ度白细胞减少发生率为11．6％(5／43)，其它不良反应较轻。结论奥沙利铂联合5-氟脲嘧啶、甲酰四氢叶酸钙对晚期大肠癌有明显疗效，多数患者能耐受。

The Clinical Observation of Oxaliplatin with 5-fluorouracil,Leucovorin in the Treatment of Advanced Colorectal Cancer

Objective To observe the clinical effect of Oxaliplatin with 5-fluorouracil,Leucovorin in the treatment of advanced colorectal cancer.Methods Forty-uhree patients with advanced colorectal cancer were selected and adopt Oxaliplation 130 mg/m2 intravenous drip 2 hours(the first day),Leucovorin 200 mg/m2 intravenous drip 2 hours(from the first day to the fifth day),5-fluorouracil 400 mg/m2 intravenous drip over 8 hours(from the first day to the fifth day).Results The total response rate of this group was 48.8%(21/43) including 1 CR and 20 PR.The median PFS was 10.1months and the median survival was 20.7 months.The main toxicities were Bone marrow depression and neurotoxicity,11.6%(5/43) patients developed Grade 3 WHO toxicity of leukopenia.other toxicities were mild.Conclusion Oxaliplatin with 5-fluorouracil,Leucovorin was obviously therapeutic effect in the treatment of advanced colorectal cancer.It could effectively extend the survival period.Most of patients could be tolerant.