Impact of MHC Class I Gene on Resistance to Murine AIDS |
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| Authors: | M MAKINO† D B MURPHY‡ R W MELVOLD§ J W HARTLEY H C MORSE III |
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| Institution: | Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA;;Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University, Kagoshima, Japan;Wadsworth Center, NY State Department of Health, Albany, NY, USA;Northwestern University Medical School, Department of Microbiology/Immunology, Chicago, IL, USA |
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| Abstract: | Development of murine AIDS in mice following infection with LP-BM5 murine leukaemia virus (MuLV) is highly strain dependent, with strain differences determind by genes within and outside H-2. Among H-2 genes, the Dd gene is the most closely associated with resistance to LP-BM5 MuLV infection. However, the Dd-mediated resistance is highly influenced by outside H-2 genes, i. e. A lineage strains are more resistant than mice strains of B6/B10 lineage. In this study, the mice having BALB background were analysed and, similarly to A lineage mice, only Dd gene products were found to be required to provide resistance to LP-BM5 MuLV infection. Furthermore, BALB/c Kh mice bearing both Dd and Ld genes clearly showed obviously higher resistance than BALB/c-H-2dm2 mice solely having the Dd gene. In addition, in the long-term observation of the effect of the Dd gene on B6/B10 background mice, D8 mice having the Dd gene as a transgene and expressing a high level Dd gene product showed higher resistance than naturally recombinant B10. A(18R) mice. These results suggest that the MAIDS resistance associated with the D end loci is dependent on the level of expression of an MHC class I gene. |
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