肝素治疗儿童肾病综合征前后血浆纤维蛋白原的变化分析

目的了解肝素的抗凝作用治疗儿童肾病综合征的疗效.方法76例儿童肾病综合征,随机分为两组,使用肝素组为治疗组,未使用为对照组,分别测量其治疗前后血浆纤维蛋白原的变化,进行统计学分析.结果两组治疗前后血浆纤维蛋白原的含量无显著性差异,而在治疗后则有差异(t=1.56,P《0.05);同组内治疗前后比较均有显著性差异(分别为t=11.47和t=5.786,P《0.001).结论使用肝素的抗凝作用治疗儿童肾病综合症,可以加强疗效,减轻肾脏的炎性反应,缓解肾小球硬化过程,防止肾功能衰竭.

Changes in Plasma-fibrinogen before and after the Treatment of Childhood Nephritic Syndrome with Heparin

Objective To observe the anticoagulant effect of heparin on childhood nephritic syndrome. Methods Seventy-six cases of nephritic syndrome were randomly divided into two groups;the treatment group and the control group.The plasma-fibrinogen was measured before and after the treatment respectively,and the results were statistically analysed.Results There was no significant difference in plasma-fibrinogen content between the two groups before the treatment,whereas significant difference was found after the treatment( t =1 56, P <0 05);significantly different plasma-fibrinogen contents were seen in the treatment group before and after the treatment( t =11.47 and t =5.786 respectively; P <0.001).Conclusion The anticoagulant effect of heparin can reinforce the therapeutic effect,alleviate the inflammatory reaction in kidney,slow down fibrosis of glomerulus,and prevent renal failure.