血清载脂蛋白人群分布特征及与血脂的关系

目的 :分析自然人群中载脂蛋白 (apo)AⅠ、AⅡ、B、CⅡ、CⅢ和E的性别、年龄分布特征 ,及与血脂的关系。方法 :1999年 9月至 10月在北京市自然人群中采用分层随机抽样进行横断面研究。1174名 35～ 6 4岁的男女两性测定了apoAⅠ、AⅡ、B、CⅡ、CⅢ、E和血脂。结果 :1 人群apoAⅠ、AⅡ、B呈正态分布 ,CⅡ、CⅢ和E呈对数正态分布。 2 35～ 6 4岁女性各载脂蛋白均随年龄的增加而升高 ,男性仅apoAⅠ随年龄的增加而升高。 3 男性apoAⅠ低于女性 ,apoAⅡ、B、CⅡ、CⅢ高于女性。女性绝经后各载脂蛋白水平较绝经前高 (P <0 0 5 )。 4 高胆固醇血症 (或混合型高脂血症 )者各种载脂蛋白均升高 (P<0 0 1) ,单纯低高密度脂蛋白血症者AⅠ、AⅡ和CⅢ显著降低 (P <0 0 5 )。 5 多因素分析表明 :apoB与非高密度脂蛋白胆固醇 (nHDL C)相关最强 ,男女两性的偏相关平方 (PartialR2 )分别为 0 6 5 8和 0 76 9,但它与低密度脂蛋白胆固醇 (LDL C)的相关则较弱 ,男女两性的PartialR2 分别为 0 2 43和 0 183;apoAⅠ与HDL C的相关最强 ,男女两性的PartialR2 分别为 0 2 82和 0 2 38;apoCⅢ与男性TG和绝经前女性TG的相关最强PartialR2 分别为 0 6 2 9和 0 6 37。结论 :人群载脂蛋白水平与性别、年龄和绝经状况有关 :3

The distribution of serum apolipoproteins and their association with lipids

Objective:To examine the distribution of apolipoprotein(apo)AⅠ,AⅡ,B,CⅡ,CⅢ and E in population,and to evaluate their association with lipids.Method:A cross-sectional study was carried out in a natural population of Beijing in 1999,using stratified-random sampling method.Serum apoAⅠ,AⅡ,B,CⅡ,CⅢ,E and lipids were measured in 1174 subjects,aged 35～64.Results:(1)The distributions of apoAⅠ,AⅡ and B were normal,whereas those for apo CⅡ,CⅢ and E were log-normal.(2)Apolipoproteins tended to increase with age in females,while only apoAⅠ increased with age in males.(3)ApoAⅠ was significantly lower,and apoAⅡ,B,CⅡ,CⅢ levels higher in men than in women.Apolipoproteins increased remarkably after menopause in females( P <0 05).(4)All apos increased in hypercholesterolemias(or combined hyperlipidemias);apoAⅠ and CⅢ decreased in hypoalphalipoproteinemias( P <0 05).(5)Multiple regression analyses showed that apoB associated with non HDL-C more closely than with others(Partial R+2 was 0.658 in men and 0.769 in women).However its relation with LDL-C was rather weak(Partial R+2 was 0.243 for men and 0.183 for women).ApoAⅠ accounted for 28.2% and 23.8% of the variation in HDL-C in men and women,respectively.ApoCⅢ was the main apolipoprotein associated with triglyceride level of men and women before menopause.Conclusion:Apolipoprotein levels related with age,sex and menopause status.Apolipoproteins associated closely with lipid levels.