| 趋化因子受体CXCR4在胃癌颈部转移淋巴结中表达的研究 |
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| 引用本文： | 田立宁,王铁,高梅鷟,吕洪光.趋化因子受体CXCR4在胃癌颈部转移淋巴结中表达的研究[J].国际遗传学杂志,2005,32(1):234-236. |
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| 作者姓名： | 田立宁 王铁 高梅鷟 吕洪光 |
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| 作者单位： | 哈尔滨医科大学附属第一医院耳鼻喉及头颈外科,150001;哈尔滨医科大学附属肿瘤医院胃肠外科,150081;哈尔滨医科大学附属第一医院普外科,150001; |
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| 摘 要： | 目的 研究趋化因子受体CXCR4在胃癌转移性淋巴结中表达的情况.方法 应用免疫组化韵方法研究胃癌患者颈部转移性淋巴结、非转移性淋巴结及健康人颈部正常淋巴结CXCR4的表达情况.结果 实验组1(胃癌颈淋巴结转移)CXCR4的阳性率为98.1%,与实验组2(胃癌颈部非转移淋巴结)对照组比较差异具有统计学意义.结论 CXCR4在胃癌的转移过程中有重要的作用.
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| 关 键 词： | 胃癌 淋巴结转移 |
The Expression of Chemokine Receptor CXCR4 in the Cervical Metastatic Lymph Nodes in Patients with Gastric Carcinoma |
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| TIAN Li-ning,WANG Tie,GAO Mei-zhuo,LU Hong-guang.The Expression of Chemokine Receptor CXCR4 in the Cervical Metastatic Lymph Nodes in Patients with Gastric Carcinoma[J].International JOurnal of Genetics,2005,32(1):234-236. |
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| Authors: | TIAN Li-ning WANG Tie GAO Mei-zhuo LU Hong-guang |
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| Abstract: | Objective To analyse the expression of chemokine CXCR4 in cervical metastatic lymph nodes in patients with gastric carcinoma. Methods Cervical lymph nodes sections of patients with gastric car-einoma and healthy people were immunohistochemically stained using a CXCR4 monoclonal antibody. ResultsThe expression rate of CXCR4 in the experimental group 1 was 98.1%, which was significantly higher than that of experimental group 2 and control group. Conclusions CXCR4 may play an important role in the metas-tasis of gastric carcinoma. |
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| Keywords: | CXCR4CXCR4Gastric carcinomaLymph nodes metastasis |
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