| 瑞格列奈或格列美脲联合甘精胰岛素治疗2型糖尿病的观察 |
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| 引用本文： | 徐向进,林忆阳,李春梅,张胜利,李忆农,冯修高.瑞格列奈或格列美脲联合甘精胰岛素治疗2型糖尿病的观察[J].中华内分泌代谢杂志,2008,24(2). |
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| 作者姓名： | 徐向进 林忆阳 李春梅 张胜利 李忆农 冯修高 |
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| 作者单位： | 南京军区福州总医院内分泌科,福州,350025 |
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| 摘 要： | 比较瑞格列奈组(31例)及格列美脲组(32例)联合甘精胰岛素治疗对继发性磺脲类药物失效的2型糖尿病患者糖代谢指标和胰岛β细胞分泌功能的影响.两组治疗6个月后餐前和餐后的末梢血糖及HbA1C较治疗前明显下降(均P＜0.01),但瑞格列奈(2 mg tid)联合甘精胰岛素控制餐后血糖、HbA1C和改善胰岛β细胞分泌功能较格列美脲(4 mg qd)联合组更好.
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| 关 键 词： | 糖尿病 瑞格列奈 格列美脲 甘精胰岛素 |
Clinical observation of repaglinide or glimepiride combined with glargine in the treatment of type 2 diabetic patients |
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| XU Xiang-jin,LIN Yi-yang,LI Chun-mei,ZHANG Sheng-li,LI Yi-nong,FENG Xiu-gao.Clinical observation of repaglinide or glimepiride combined with glargine in the treatment of type 2 diabetic patients[J].Chinese Journal of Endocrinology and Metabolism,2008,24(2). |
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| Authors: | XU Xiang-jin LIN Yi-yang LI Chun-mei ZHANG Sheng-li LI Yi-nong FENG Xiu-gao |
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| Abstract: | The effects of repaglinide combined with glargine (n=31)on glucose metabolism and β-cell function were observed in the patients with type 2 diabetes after secondary sulfonylureas failure and the results were compared with glimepiride combined with glargine (n=32). The preprandial capillary blood glucose, postprandial capillary blood glucose and HbA1C in both groups after 6-month treatment were significantly reduced as compared with those at baseline (all P＜0.01). The treatment with repaglinide(2 mg tid) plus glargine was more efficient than glimepiride(4 mg qd) plus glargine in improving β-cell function, ameliorating HbA1C and postprandial blood glucose excursions in patients with type 2 diabetes. |
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| Keywords: | Diabetes mellitus Repaglinide Glimepiride Glargine |
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