妥泰治疗癫痫的临床观察

目的：观察妥泰(托吡酯topiramate，TPM)治疗癫痫的效果、剂量及安全性。方法：初始剂量成人25mg／d，儿童12．5mg／d，观察并记录癫痫发作次数。症状控制者不再加药。症状控制减少或不能控制继续加量。最高剂量350mg／d，最低剂量50mg／d。先观察3mo内结果，随后观察48wk癫痫控制结果，记录发作次数，副反应及出现时间。结果：35例病人完全控制3mo为71．43％，6mo为76％；症状基本控制3mo为17．14％，6mo为20％；改善不明显和无效3mo为17．14％，6mo为20％；副反应发生率68％，多数症状轻微，对症处理后好转，严重者占少数。结论：TPM治疗癫痫疗效明显，较为安全，治疗剂量应个体化。

CLINICAL OBSERVATION OF TREATING THE EPILEPSY WITH TOPIRAMATE

Objective: A clinical trial was conducted to observe the effect,dosage and security of topiramate (TPM) therapy for epilepsy. Methods: The starting doses of TPM were 25 mg/d for adult and 12.5 mg/d for child. We observed and recorded the times of seizures for three months. Keeping the dose for the patients that symptom was controlled,increasing the dose for the patients that symptom was not controlled or controlled was reduction, The maximum doses were 350 mg/d, the minimum doses were 50 mg/d. Thereafter we followed 48 weeks, and recorded the frequency of seizures, side effect and arose time of that. Results: 35 patients entered the study. Symptom controlled rate was 71.43% after three months, after six months was 76%. Symptom mostly controlled rate was 17.14% after three months, after six months was 20%. Rate of ineffective or indistinctive effect was 17.14% after three months, after six months was 20%. Side effect rate was 68% and mostly were slight, all patients were improve after treated, and few had serious side effect. Conclusion: TPM was effective and safe, dosage should be individuation.