肝性脑病与褪黑素关系的初步研究

目的:研究血清褪黑素与肝性脑病发生的关系。方法:用酶联法测定伴有肝性脑病肝硬化组和无肝性脑病肝硬化组血清4Am褪黑素,取正常参照组做比较。并动态测定肝性脑病发病期和恢复期的血清褪黑素浓度。结果:肝性脑病组血清褪黑素比单纯肝硬化组高,两组均比正常参照组高。分别为(308.53±59.07)ng/L、(139.85±34.59)ng/L、(77.73±28.4)ng/L。肝性脑病发病期比恢复期高(P＜0.01),分别为(301.52±66.42)ng/L和(147.81±23.31)ng/L。结论:血清褪黑素水平升高可能与肝性脑病有密切联系。

Study on the relationship between melatonin and hepatic encephalopathy

AIM:To explore the relationship between change of serum melatonin (MT) and pathogenesis of hepatic encephalopathy (HE). METHODS: Changes of MT level in sera of cirrhosic patients with HE and without HE were determined by ELISA, normal serum served as control. The change of serum MT level in exacerbation and remission in HE was also determined.RESULTS:MT level in patients with HE was higher than that withour HE (P＜0.01). MT levels of both groups were higher than that of normal group (P＜0.01). They were (308.53±59.07) ng/L, (139.85±34.59)ng/L,(77.73±28.41)ng/L, respectively. Serum MT level in exacerbation was higher than that in remission (P＜0.01), they were (301.52±66.42)ng/L and (147.81±23.31) ng/L, respectively. CONCLUSION: The elevation of MT content in sera may be closely related to the onset of hepatic coma.