~(131)I治疗Graves病320例疗效影响因素分析

目的 :探讨Graves病13 1I治疗 32 0例疗效影响因素。方法 :Graves病患者 32 0例 ,根据预测影响因素 :性别、年龄、病程、停ATD时间、甲状腺最高吸碘率、有效半衰期、TT4、TT3 、FT4、STSH、TgAb、TmAb、Tg、甲状腺质量、每克甲状腺组织给予13 1I计量、甲状腺质地、有无突眼、分别量化各项指标值。疗效按甲低、治愈、未愈进行评价 ,经统计学处理。结果 :13 1I治疗 12个月出现甲低者 19.71% ,治愈 (治疗后正常 +甲低 )者 90.0 3% ,未愈者 10.0 0 %。年龄、甲状腺最高吸碘率、有效半衰期、甲状腺质量、每克甲状腺组织给予13 1I计量对13 1I治疗疗效有统计学意义 (P<0.0 5 )。结论 :对甲状腺最高吸碘率低伴有效半衰期长、甲状腺质量较小、年龄较小、每克甲状腺组织给予13 1I计量应偏小 ,否则13 1I计量应偏大

Multiple Factor Analysis of the Therapeutic Effect of ~(131)I in Treating 320 Cases of Graves'''' Disease

Objective:To study the factors influencing therapeutic effect of ~(131) I in treating 320 cases of (Graves') disease.Methods:The values of various indexes were quantized on forcasted influencing factors such as age,sex,course of disease,etc.The assessment of the therapeutic effect was made according to hypothyroidism,cure,and improvement.Logistic test was used to analyze the variable parameters before treatment.Results:After 12 months 90.03% of the cases were cured,10.00% were not cured and 19.71% became hypothyroidism.The outcome of treatment was related to age,thyroid tiptop uptake percentage,effective half-life,the weight of thyroid and the absorbed dose of ~(131) I per gram of thryoid tissue(P<0.05).Conclusion:In those young patients whose thyroid tiptop uptake percentage was lower,the effective half-life was longer and thyroid weight was smaller,the given ~(131) I dose per gram tissue of thyroid should be reduced.