唾液酸和微量白蛋白尿与2型糖尿病合并症的关系

目的研究唾液酸、尿微量白蛋白与2型糖尿病合并症的关系。方法健康对照组44例，2型糖尿病无合并症组44例，2型糖尿病合并肾病组44例，2型糖尿病合并视网膜病变组30例。采集静脉血样和随机尿样。血样检测唾液酸和血脂谱、血糖、HbA1C、C-反应蛋白，随机尿样检测尿微量白蛋白和唾液酸。并测量各组体质量指数（BMI）、血压、腰围比。结果各糖尿病组血和尿唾液酸含量比对照组显著增高（P〈0．01）。血清唾液酸含量明显增加的趋势显示合并肾病的严重性和尿白蛋白排出的程度（P〈0．01）。糖尿病。肾病患者的血清唾液酸含量和尿白蛋白含量明显高于其他患者（P〈0．01）。血清唾液酸含量与尿微量白蛋白明显正相关（r=0．263，P〈0．01），与腰围比明显正相关（r=0．226，P〈0．05），与收缩压明显正相关（r=0．263，P〈0．01），与C反应蛋白和血脂没有相关性。尿微量白蛋白含量与腰围比成正相关（r=0．301，P〈0．05），与收缩压成正相关（r=0．633，P〈0．01）。结论血清唾液酸含量的增加和尿微量白蛋白与2型糖尿病合并肾病、糖尿病合并视网膜病以及糖尿病心血管病的危险因子如高血压、高腰围比密切相关，两者可以作为2型糖尿病微血管合并症的检查指标。

Relationship of Sialic Acid Concentrations and Microalbuminuria with Type 2 Diabetic Complications

Objective To study the relationship of sialic acid concentrations and microalbuminuria with type 2 diabetic complications. Methods The subjects aged 15-65 years with type 2 diabetes were recruited for the study. Fasting venous blood samples were collected from 44 healthy individuals, 44 patients with type 2 diabetes, 44 patients with type 2 diabetes and nephropathy, and 30 patients with diabetes and retinopathy. Simultaneously urine samples were also collected from each of the subjects. All the blood samples were processed for lipid profile, glucose, HbAIC, C- reactive protein and sialic acid. The urine samples were analyzed for sialic acid and microalbumin. The comparisons within and among the groups were done using one way ANOVA test. Pearson＇ s correlation test was used for correlation study. Results Serum sialic acid concentrations were significantly higher among diabetic subjects as compared to the controls （P〈0.01）. There was a significant increasing trend of serum sialic acid with severity of nephropathy and degree of urinary albumin excretion （P〈 0.01）. The diabetic retinopathy patients also demonstrated significantly higher values of serum sialic acid and urine microalbumin （ P 〈 0.0l）. Sialic acid had no correlation with CRP or any component of the lipid profile. Serum sialic acid significantly positively correlated with urine microalbumin （r = 0. 263, P〈 0.0l）, waist/hip ratio （r = 0. 226, P〈 0.05） and systolic blood pressure （r = 0. 263, P〈 0.0l）. Urine microalbumin significantly positively correlated with waist/hip ratio （r = 0. 301, P 〈 0.05） and systolic blood pressure （ r = 0. 633, P 〈 0.01 ）. Conclusions The increased serum sialic acid and microalbumin are closely related to the presence of microvascular complications like diabetic nephropathy and diabetic retinopathy, anti cardiovascular risk factors like hypertension and waist to hip ratios in type- 2 diabetic patients, and may be used as two indicators of type- 2 diabetic patients＇ complicati