健择联合腹腔灌注顺铂治疗胆系恶性肿瘤的临床研究

目的研究健择联合顺铂进行腹腔区域性热化疗治疗恶性胆系肿瘤的疗效,寻找合适的恶性胆系肿瘤内科治疗方案.方法分别选择全身静脉应用健择联合腹腔灌注顺铂结合体外射频热疗(试验组,n=24)、全身静脉应用吡柔比星联合腹腔灌注顺铂(对照组,n=25)对胆系恶性肿瘤进行治疗,比较治疗效果.结果全身静脉应用健择联合腹腔灌注顺铂结合体外射频热疗实验组的有效率和临床获益率均明显高于全身静脉应用吡柔比星联合腹腔灌注顺铂对照组(P<0.05, P<0.01);试验组的生活质量评分明显优于对照组(P<0.01).结论全身静脉应用健择联合腹腔灌注顺铂结合体外射频热疗对恶性胆系肿瘤有明显的治疗效果,毒副作用小,患者可耐受.

Combination of gemcitabine intravenous injection and cisplatin peritoneal perfusion for biliary malignancies

Objective To study the effects of gemcitabine and cisplatin combination in the treatment of malignancies of biliary tree and investigate proper chemotherapeutic regimens.Methods Twenty-four patients with malignancies of biliary tree were treated with gemcitabine intravenous injection and cisplatin intraperitoneal perfusion,followed by RF thermotherapy at the hepatic region(experiment group),25 patients applied to pirarubicin intravenous injection and cisplatin intraperitoneal perfusion(control group).The curative effects were analyzed.Results Forty-nine patients all completed the treatment.The overall response rate and clinical profit rate were higher in experiment group than control group(P<0.05 and P<0.01).The quality of life score was higher in experiment group than control group (P<0.01).Conclusion The combination of gemcitabine intravenous injection and cisplatin intraperitoneal perfusion has significant curative effect on malignancies of biliary tree,with fewer side effects and more tolerance to patients.