Effects of the Chinese herbal medicine "saiboku-to" on histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80 |
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| Authors: | S Toda M Kimura M Ohnishi K Nakashima |
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| Institution: | Department of Pharmaceutical Science, Kansai Shinkyu Medical College, Osaka, Japan. |
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| Abstract: | The herbal medicine "Saiboku-to" (ST) has been used for the treatment of bronchial asthma. ST was found to inhibit histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80. Its inhibitory effects were concentration-related and somewhat weaker than disodium cromoglycate, a known inhibitor of histamine release and mast cell degranulation. From these results, ST could appear to be useful in the treatment of Type I allergic reactions. |
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