Depletion by capsaicin of substance P-immunoreactivity and acetylcholinesterase activity from nerve fibres in the guinea-pig heart |
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| Authors: | R E Papka J B Furness N G Della M Costa |
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| Institution: | 1. Centre for Neuroscience, Flinders University of South Australia, Bedford Park, South Australia 5042 Australia;2. Department of Human Morphology, Flinders University of South Australia, Bedford Park, South Australia 5042 Australia;3. Department of Human Physiology, Flinders University of South Australia, Bedford Park, South Australia 5042 Australia |
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| Abstract: | The sensitivity to capsaicin of substance P-immunoreactive nerve fibres in the hearts of guinea-pigs was examined. Capsaicin decreased considerably the substance P-immunoreactive material in nerve fibres of the parietal pericardium, atria, bicuspid and tricuspid valves. Pericardial and valvar nerve fibres localized by acetylcholinesterase (AChE) histochemistry had a distribution and density pattern similar to that of the substance P immunoreactive fibres. Capsaicin treatment also decreased the number of visible AChE-positive nerve fibres. It is known that capsaicin has a selective action on those substance P-immunoreactive fibres that are of sensory origin; thus, these results imply that substance P-immunoreactive fibres in the heart are sensory. Moreover, the results suggest that some of the nerve fibres localized in the heart by AChE histochemistry are substance P-containing sensory fibres. |
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| Keywords: | To whom correspondence should be addressed |
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