| 儿童实体恶性肿瘤抗癌药物敏感试验 |
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| 引用本文： | 金先庆 汤为学. 儿童实体恶性肿瘤抗癌药物敏感试验[J]. 中华小儿外科杂志, 1995, 16(5): 265-267 |
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| 作者姓名： | 金先庆 汤为学 |
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| 作者单位： | 重庆医科大学儿童医院外科，重庆医科大学病理生理教研室 |
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| 摘 要： | 本文采用ＭＴＴ法对１０例淋巴肉瘤、神经母细胞瘤、肾母细胞瘤等实体恶性肿瘤患儿作抗癌药物敏感试验。结果显示ＶＰ－１６、丝裂霉素及顺铂等抗癌药物对儿童实体恶性肿瘤较为敏感。本文讨论了影响试验结果的三个主要因素：肿瘤细胞浓度，培养时间及药物浓度。笔者认为ＭＴＴ法是一种简便易行重复性好的试验方法，抗癌药物敏感试验应逐渐成为化疗药物选择的重要依据。
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| 关 键 词： | 儿童，恶性肿瘤，MTT法，化疗 |
Determination of Anticancer Drug Sensitivity in Children With Malignant Solid Tumor |
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| Jin Xianqing,Tang Weixue,Weng Shan,et al.. Determination of Anticancer Drug Sensitivity in Children With Malignant Solid Tumor[J]. Chinese Journal of Pediatric Surgery, 1995, 16(5): 265-267 |
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| Authors: | Jin Xianqing Tang Weixue Weng Shan et al. |
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| Abstract: | Ten samples from malignant solid tumors including lymphosarcoma, neuroblastoma.Wilms' tumor in children were examined. It was found that MTT colorimetric assay would be a simple,rapid and reliable method for anticancer drug sensitivity in children with malignant solid tumor.VP16,MMC and CAR are the three most sensitive anticancer drugs for certain sarcomas and malignant embryonic tumors.The optimal concentration of tumor cells,the optimal incubation time for the action of anticancer drugs on tumor cells and the concentration of anticancer drugs are discussed.Routine determination of anticancer drug sensitivity before the selection of anticancer drug for children with malignant solid tumor would be preferable. |
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| Keywords: | Anticancer drug sensitivity test Malignant solid tumor |
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