| 小儿常见恶性实体瘤多药耐药性蛋白的定位检测 |
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| 引用本文： | 步星耀,金百祥.小儿常见恶性实体瘤多药耐药性蛋白的定位检测[J].中华小儿外科杂志,1995,16(5):262-264. |
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| 作者姓名： | 步星耀 金百祥 |
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| 作者单位： | 上海医科大学儿科医院外科，上海医科大学肿瘤医院临床药理实验室 |
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| 摘 要： | 对４９例小儿常见恶性实体瘤冰冻切片进行多药耐药蛋白（Ｐ－１７０）的免疫组化定位检测。术前化疗肿瘤多药耐药性蛋白阳性率为肾母细胞瘤４４％（４／９），神经母细胞瘤１００％（７／７），横纹肌肉瘤７５％（３／４），术前未化疗肿瘤多药耐药性蛋白的阳性率为肾母细胞瘤２３％（３／１３），神经母细胞瘤４０％（４／１０），横纹肌肉瘤３３％（２／６）。小儿恶性肿瘤多药耐药性检测对揭示肿瘤耐药、复发的原因，估计化疗效果和判断预后以及指导化学治疗具有一定意义。
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| 关 键 词： | 耐药性，免疫组织化学，肾母细胞瘤，神经母细胞瘤，横纹肌肉瘤 |
Detection of Multidrug Resistance Protein in Children With Malignant Tumor |
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| Bu Xingyao,Jin Baixiang,He Zhiming..Detection of Multidrug Resistance Protein in Children With Malignant Tumor[J].Chinese Journal of Pediatric Surgery,1995,16(5):262-264. |
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| Authors: | Bu Xingyao Jin Baixiang He Zhiming |
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| Abstract: | Frozen tissue from 49 malignant tumors was studied by immnohistochemical method for multidrug resistance protenin(p-170).The detectable rates of multidrug resistance protein in preoperative chemotherapeutic nephroblastoma,neuroblastoma and rhabdomyosacoma were 44%(4/9),100%(7/7)and 75% (3/4)respectively ,while in preoperative chemotherapy-free nephroblastoma,neuroblastoma and rhabdomyosacoma were 23%(3/13),40%(4/10)and 33%(2/6)respectively.The biologic and clinical significance of the results are discussed. |
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| Keywords: | Drug resistance Immunohistochemistry Nephroblastoma Neuroblastoma Rabdomyosarcoma |
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