矿物药玄明粉与无水硫酸钠的构效对比研究

目的 对比研究矿物药玄明粉与无水硫酸钠结构与药效差异，探索二者的作用机制。方法 采用AXIOS型X射线荧光光谱法对二者结构进行比较；采用小鼠胃排空、肠推进模型和复方地芬诺酯所致便秘模型对二者药效进行比较。结果 玄明粉有正交和立方两种晶型，无水硫酸钠只有正交晶型；除共有化学组成外，玄明粉还含有Al₂O₃、K₂O、SrO、ZnO、Cl^?，无水硫酸钠仅有Fe₂O₃；药效对比实验中，发现二者对小肠运动的影响具有显著性差异（P＜0.01）。结论 玄明粉与无水硫酸钠在结构和药效上存在一定的差异，实验结果可为临床应用提供参考依据。

Comparison on structure-efficacy between mineral drugs weathered sodium sulfate and anhydrous sodium sulfate

Objective To compare the differences between weathered sodium sulfate (WSS) and anhydrous sodium sulfate (ASS) from structure and part potency and to explore the mechanism of action. Methods AXIOS X-ray Fluorescence Spectrometer was applied to analyze structure. We selected the model of gastric emptying, intestinal propulsion, and Compound Diphenoxylate-induced constipation. Results The result showed that there were two crystal forms: orthogonality and cube in WSS, while only orthogonality in ASS; Meanwhile, after analyzing the microelement of the two by X-ray Fluorescence Spectrometer, we found out that the common materials, yet, in WSS there were more Al₂O₃, K₂O, SrO, ZnO, and Cl^?, while there was only Fe₂O₃ in ASS. When comparing the medicative function of the two, we found out that there was an obvious difference (P < 0.01). Conclusion There are some differences in structure and medicative function, which could provide the reference basis for clinical application.