高原地区联合应用美托洛尔、卡托普利治疗慢性充血性心力衰竭观察

目的观察在高原地区应用美托洛尔联合卡托普利治疗慢性充血性心力衰竭患者（CHF）的疗效。方法选择心功能2～4级,左室增大、左室收缩末期容量增大及左室射血分数（LVEF）≤40%,有基础心脏病病史,有或无呼吸困难、乏力和体液潴留（水肿）等症状的患者40例,随机分为治疗组和对照组,对照组应用小剂量洋地黄、利尿剂、扩血管药物,治疗组在对照组基础上加用小剂量美托洛尔及卡托普利,6个月后进行比较。结果治疗组患者在左室舒张末内径（LVEDD）、左室射血分数（LVEF）、6min步行距离试验（6-MWT）结果上差异均有统计学意义（P〈0.05）。结论高原地区在传统治疗心力衰竭的基础上联合应用美托洛尔和卡托普利疗效显著。

Observation of metoprolol and captopril in treatment of chronic congestive heart failure in plateau regions

Objective To observe the efficacy of using metoprolol combined with captopril in treatment of chronic conges tive heart failure (CHF) in plateau regions.Methods Forty patients were chosen as subjects.With heart function at grade (NYHA) 2-4,they were suffered from left ventricular enlargement,left ventricular end-systolic volume increase as well as LVEF ≤40%,and had history of basic heart disease,with or without symptoms such as difficulty in breathing,lack of strength,and fluid retention (edema).The subjects were randomized into treatment group and control group.Small doses of digitalis,diuretic,and vascular dilation drugs were used on the control group,while small doses of metoprolol and captopril in addition to those given to the control group were administered on the treatment group.A comparison was made 6 months later.Results Patients in the treatment group showed significant differences in the results of left ventricular end-diastolic diameter (LVEDD),left ventricular ejection fraction (LVEF),and 6-minute walking test (6-MWT) (P < 0.05).Conclusion Combining metoprolol and captopril with traditional therapies on heart failure in plateau regions has significant efficacy.