再生障碍性贫血患者的T淋巴细胞亚群与病毒感染关系的探究

目的通过回顾性分析临床资料，探讨再生障碍性贫血患者的T淋巴细胞亚群与病毒感染之间的相互关系。方法对50例再生障碍性贫血患儿和50例正常儿童分别进行病毒检测和淋巴细胞亚群CD4、CD8的检测，对结果进行分析。结果再生障碍性贫血患者病毒感染阳性率明显高于对照组，且再生障碍性贫血患者外周血中CD4细胞下降，CD8细胞增多，CD4／CD8比例下降。结论病毒感染能刺激机体免疫系统并使之对造血干细胞、祖细胞或基质细胞发生异常免疫反应，进而损伤或抑制造血功能；免疫功能的紊乱使病毒容易入侵机体，并难以清除。本研究对治疗再生障碍性贫血有指导意义。

Study of the relations between the T lymphoblastic subgroup of aplitic anemia patients and virus infection

Objective To explore the relations between the T lymphoblastic subgroup of aplitic anemia patients and virus infection,through the analysis of the clinical data were retrospectively.Methods The results concluded through examinations of viruses and lymphoblastic subgroup cells of CD4,CD8 from 50 cases of child patients and 50 cases of normal ones were analyzed.Results Aplitic anemia patients had significant positive infection rate than the reference group,as well as the CD4 cells were decrease,CD8 cells were increase,and the ratio of CD4/CD8 goes down in the outer blood.Conclusion Virus infection can stimulate organic immune system and thus induces unusual immune reactions to stem cells,mesenchymal cells,ending up with damages or restrains on the abilities of blood produce;The immune disorder makes it easy for viruses to invade into the living body that is hard to be cured.This article tries to explain how to prevent virus infections and how to regulate immune system.This study have guiding significance in treatment aplastic anemia.