苯妥英钠在血药浓度监测下治疗癫痫大发作与部分性发作73例临床观察

目的通过对苯妥英钠血药浓度的监测，观察苯妥英钠治疗73例癫痫患者的临床疗效。方法随机将本院门诊和住院收治的癫痫患者219例分为苯妥英钠（PHT）治疗组（n=73）、苯妥英钠（PHT）对照组（n=73）、苯妥英钠和苯巴比妥（PHT＋PB）双药组（n=73），并对治疗组的患者进行治疗药物监测（TDM），双药组与对照组不进行TDM，观察其临床疗效。结果显示首次3组有效率差异无统计学意义（P〉0．05），经调整DPH血药浓度后，3组疗效比较，治疗组与双药组、对照组有效率比较差异有统计学意义（P〈0．05），双药组与对照组有效率比较差异无统计学意义（P〉0．05）。结论表明控制癫痫大发作与部分性发作治疗组的个体化给药较双药组、对照组效果佳。

Clinical observation on 73 patients of the full and part break out of epilepsy with serum Phenytoin monitoring

Objective To observe the clinical curative effect of Phenytoin sodium on 73 patients with epilepsy by monitoring of phenytoin sodium serum concentration.Methods Two hundred and nineteen patients were randomly divided into treated group(PHT,n = 73) and contrastive group(PHT,n = 73) and double medicines group(PHT+PB,n = 73) in our hospital outpatient service and be in hospital.The serum concentraction of therapeutic drug monitoring(TDM) were mesdured in treated grorp.It was no measured in double medicines group and contrastive group,the clinical curative effect were observed.Results The effective rate of each group showed the difference was no statistically significant(P > 0.05).After abjusting the serum concentration of PHT,the effective rate of treated group showed the difference was statistically significant with the other two groups(P < 0.05),but double medicine group and contrastive group showed the difference was no statistically significant(P > 0.05).Conclusion It show that the control the full and part break out of epilepsy for individualized administration,the treated group is better then the double medicine group and contrastive group.