p53蛋白表达在直肠肿瘤中病理意义

目的研究p53蛋白在结直肠肿瘤中的表达及病理意义。方法采用免疫组织化学法检测p53在33例结直肠绒毛状腺癌、32例绒毛状腺瘤、15例非肿瘤黏膜组织中的表达。结果p53在结直肠绒毛状腺癌、绒毛状腺瘤、非肿瘤黏膜的阳性表达率分别为：75．7％（25／33）、59．4％（19／32）、13．3％（2115）。p53蛋白表达强度：结直肠绒毛状腺癌〉绒毛状腺瘤〉非肿瘤黏膜（R从大至1,），其中结直肠绒毛状腺癌和绒毛状腺瘤R的95％可信限下界均高于非肿瘤的上界，差异有统计学意义。结论p53基因突变及其产物p53蛋白的检测，用于早期发现结直肠腺癌具有重要的病理诊断意义。

Pathological significance of p53 protein expression in rectal cancer

Objective To study the pathological significance of p53 protein expression in rectal cancer.Methods Immunohistochemical techniques were used to detect the expression of p53 protein in 33 cases of colorectal papillary adenoma,32 cases of villous adenoma and 15 cases of non-tumor mucosa tissue.Results The ratios of positive expression of p53 protein in colorectal papillary adenoma,villous adenoma and non-tumor mucosa were 75.7%(25/33),59.4%(19/32) and 13.3%(2/15),respectively.The intensity order of the expression of p53 protein was colorectal papillary adenocarcinoma > villous adenomas > non-tumor mucosa(R from big to small).The lower limits of 95% confidence interval of R values in both colorectal papillary adenoma and villous adenoma were higher than the upper limit in non-tumor mucosa,and there were significant differences.Conclusion The detections of p53 gene mutation and p53 protein contribute to pathological diagnosis of early colorectal adenocarcinoma.