兰索拉唑联合曲美布丁治疗反流性食管病临床疗效观察

目的探讨兰索拉唑联合曲美布丁治疗非糜烂性食管病（NERD）的疗效。方法将120例NERD患者随机分成两组，治疗组60例，给予兰索拉唑片30mg，qd，曲美布丁200mg，tid，口服。对照组60例，给予兰索拉唑30mg，qd，口服。疗程均为8周。根据耐信量表进行症状评分。结果治疗组总有效率为93％，对照组总有效率为82％，两组比较差异有统计学意义（P〈0．01）。治疗组临床症状改善明显优于对照组（P〈0．01）。结论兰索拉唑联合曲美布丁治疗非糜烂性食管病有较好的疗效。

Effects of lansoprazole combined with trimebutine in treatment of non-erosive reflux disease

Objective To investigate the efficacy of lansuolazuo combined with trimebutine in the treatment of non-erosive disease (NERD). Methods One hundred and twenty patients with NERD were randomly divided into 2 groups. The treatment group of 60 patients received lansprazole 30 mg, qd, combined with trimebutine 200 mg, tid; and the control group with another 60 patients had lansoprazole alone 30 mg, qd, po. The clinical efficacy was evaluated with a course of 8 weeks after the treatment according to measurement of reflux diagnostic questionnaire. Results The total effective rate in the treatment group was 93%, while it was 82% in the control group, the difference was significant between the two groups (P < 0.01); and with still more significant improvements of clinical symptoms in the treatment group (P < 0.01). Conclusion Lansprazole in combination with trimbutine is rather more helpful to provide the efficacy in treating NERD.