Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus |
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| Authors: | Ning Li-Li Han Jian Zhang Xing-Yi Guo Hong-Zhu Bi Kai-Shun Guo De-An |
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| Affiliation: | The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. |
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| Abstract: | Catharanthus roseus cell suspension cultures were used to bioconvert both triptolide (1) and triptonide (2). The same reaction path was followed in both biotransformations. Two biotransformed products were obtained and their structures identified as triptriolide (3) and 12beta,13alpha-dihydroxytriptonide (4), respectively, from 1 and 2. Product 4 is a new compound. |
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