Polycystic ovary syndrome in patients on antiepileptic drugs |
| |
| Authors: | Lakshminarayanapuram G Viswanathan Parthasarathy Satishchandra Bipin C Bhimani Janardhan YC Reddy Batchu S Rama Murthy Doddaballapura K Subbakrishna Sanjib Sinha |
| |
| Institution: | Department of Neurology, NIMHANS, Bengaluru, Karnataka, India;1Department of Psychiatry, NIMHANS, Bengaluru, Karnataka, India;2Srinivasa Ultrasound Scan Center, Shankarpuram, Bengaluru, Karnataka, India;3Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India |
| |
| Abstract: | Objective:This study aims to discuss the prevalence of polycystic ovary (PCO) and Polycystic ovary syndrome (PCOS) in women with epilepsy (WWE) on valproate (VPA), carbamazepine (CBZ), or phenobarbitone (PB), drug naive WWE and women with bipolar affective disorder (BPAD) on VPA.Results:Fifty-two women (52/190; 27.4%) had menstrual disturbances, in which oligomenorrhea was the most common (55.8%). There was a significant difference in the occurrence of PCOS in patients on VPA versus normal population (P = 0.05) and patients on other antiepileptic drugs (AEDs) (P = 0.02). There was, however, no significant difference in the occurrence of PCO between patients on VPA and the untreated epileptic women. VPA group (Epilepsy + BPAD) had a significantly higher occurrence of obesity than other treatment groups (P = 0.043, OR = 2.11).Conclusions:The study observed significantly higher occurrence of PCO in patients on VPA compared to other AEDs and the normal population. The importance of proper clinical evaluation before initiating VPA is highlighted. |
| |
| Keywords: | Antiepileptic drugs epilepsy Polycystic ovary syndrome valproate |
|
|
