改良换血疗法治疗新生儿高胆红素血症疗效观察

目的研究改良换血疗法治疗新生儿高胆红素血症的疗效和安全性。方法对确诊新生儿高胆红素血症(符合换血指征)的15例患儿采用腋静脉-桡动脉同步全自动换血疗法。换血在NICU辐射抢救台密闭的系统中全自动完成。监测换血前总胆红素、血红蛋白、血糖、pH、电解质及心率、呼吸、血压之变化。结果换血治疗后总胆红素换出率47.87%,换出前为(492.6±70.23)μmol/L,换血后为(249.45±47.26)μmol/L,换血前后血清总胆红素有显著性差异(p<0.01)。血红蛋白、血糖、电解质水平稳定,心率、呼吸、血压、血氧饱和度无明显波动。结论改良换血疗法操作简便、安全,是新生儿换血中理想的方法。

CLINICAL STUDY OF IMPROVED EXCHANGE TRANSFUSION IN NICU

Objective To research the effect and security of improved exchange transfusion in treating hyperbilirubinemia of nerborn. Method 15 newborns definitely diagnosed as hyperbilirubinemia （according with the indication of blood exchange） were used axillary vein -radial artery synchronized and automatieally exchange transfusion. The procedures were implemented complete automatically within the Taiwan airtight system of NICU radiation rescues platform. Monitor newborn＇ s total bilirubin, hemoglobin, blood sugar, pH, the electrolyte and the heart rate, the breath, the blood pressure before and after the transfusion. Result Around brings in new blood the trade rate of total biliruhin was 47.87%, before trading, （492.6 ± 70.23 ） umol/L, after bringing in new blood, （ around 249.45 ± 47.26 ） umol/L, there is significant difference （p 〈 0.01 ）. The hemoglobin, the blood sugar, the electrolyte level are stable, the heart rate, the breath, the blood pressure, the blood oxygen degree of saturation fluctuates not obviously. Conclusion The improved exchange transfusion is simple, safe, an ideal therapy for newborns.