髓内压对骨内液体流动行为的影响

目的 研究髓内压对骨内液体流动行为的影响。方法 利用 COMSOL Multiphysics 软件分别建立宏观大段骨组织和宏-细观骨间质-骨单元群的多尺度多孔弹性力学有限元模型,在考虑骨髓腔、哈弗氏管和骨陷窝-小管等不同孔隙尺度相互联系的情况下,对比中空骨组织和含髓内压骨组织的孔隙压力与流速情况,并分析髓内压幅值和频率对骨内液体压力和流速的影响。结果 考虑髓内压时,含髓内压骨组织比中空骨组织孔隙压力高6.4 kPa。骨内液体压力随着髓内压幅值的增加而明显增加,但流速基本不变。髓内压频率对孔隙压力和流速基本无影响。结论 建立的多级孔隙模型更精准分析了骨内液体流动行为,研究结果对深入理解骨内力传导具有重要意义。

Effects of Intramedullary Pressure on Fluid Flow Behavior in Bone

Objective To study the effects of intramedullary pressure on the fluid flow behavior in bones. Methods Multi-scale models of macro bone tissue and macro-meso osteon groups were established using The COMSOL Multiphysics software. Considering the interrelationship of different pore scales, such as the bone marrow cavity, Haversia canal, and bone lacunar-canaliculus, the pore pressure and flow rate of hollow bone tissues and bone tissues with intramedullary pressure were compared, and the effects of the amplitude and frequency of intramedullary pressure on the pressure and flow velocity of the liquid in the bone were analyzed. Results When intramedullary pressure was considered, the pore pressure in bone tissues with intramedullary pressure was 6.4 kPa higher than that in hollow bone tissues. The flow pressure increased significantly with an increase in the intramedullary pressure amplitude, but the flow velocity remained unchanged. The frequency of intramedullary pressure had little effect on pore pressure and flow velocity. Conclusions The multi-scale pore model established in this study can accurately analyze bone fluid flow behavior. These results are of great significance for an in-depth understanding of force conduction in the bone.